What is Clomid with Injections?

Clomid with injections is a combination of ovulation-inducing medication of intrauterine insemination (IUI).

For this treatment, we initially provide Clomid to induce ovulation and perform intrauterine insemination about 24-36 hours after the hCG injection. An intrauterine insemination is when the partner’s sperm is washed and concentrated into a catheter, which is then used to inject it into the uterine cavity.

How Does Clomid with Injections Work?

The procedure takes about one hour to process the sperm and another 15 minutes to perform the intrauterine insemination. The pregnancy rates are about 5% higher per cycle of stimulation.

Clomid is used primarily in women that ovulate irregularly or not at all, but it can also be used in cases of unexplained fertility. This typically creates two or more follicles (eggs) that grow in any given cycle. The risk of twins or multiples is 5-10%.

The injectable medications known as Gonal-F and Follistim are synthetic forms of Follicle Stimulating Hormone, while Menapur is a combination of Follicle Stimulating Hormone and Luteinizing Hormone. Clomid is initiated on day 3-7 and the injections are added on day 6. A pelvic ultrasound is typically done on day 10 to carefully monitor the size of the follicles. Once the follicles reach maturation, an injection of hCG is given to induce ovulation. We can also combine clomid with gonadotropins and an intrauterine insemination, which is typically done 24-36 hours after the hCG injection.

Why Choose Clomid with Injections?

In patients who have previously used clomid or have a history of low ovarian reserve, we may elect to use clomid in combination of injectable medications. The combination typically has a higher pregnancy rate (up to 35%) and the risk of multiple births is about 25%. When we use the combination of oral medication and injections, we find that we reduce the amount of injections needed while maintaining the higher pregnancy rate. The added advantage of these injections is counteracting the side effects of Clomid, while increasing the estrogen levels and the number of follicles growing.

What are the Side Effects of Clomid with Injections?

These injectable medications are potent drugs with potential side effects; you may experience:

  • Headaches
  • Irritability
  • Depression
  • Fatigue


Ovarian Hyperstimulation Syndrome is a rare risk, which leads to ovarian enlargement, abdominal distention, and difficulty breathing. This can occur in 2% of patients and unfortunately is not preventable. If you gain more than 2 lbs. daily and are unable to void, you must notify our office immediately. At AFCT, every effort is taken to prevent the risk of ovarian hyperstimulation. Please notify our office if you are experiencing any other abnormal reactions or severe abdominal pain.