Fertility Preservation
Options for Men

The cornerstone evaluation for male infertility is the semen analysis. This is one of the most important fertility test for men because male infertility is present in up to 40% of couples with infertility.

Currently, the main fertility preservation option for men is sperm cryopreservation (freezing). Men who receive a diagnosis of cancer should freeze their sperm on 2-3 occasions prior to receiving chemotherapy or radiation.

Sperm can be frozen on the same or next day after a diagnosis of cancer is made, and can be recollected every 48-72 hours prior to treatment and depending on the clinical circumstance. The advantage of freezing sperm with a Reproductive Endocrinologist (Infertility Specialist) is that intrauterine insemination or preferably IVF can later be used to conceive. Since sperm can only be frozen in small quantities, IVF provides the best opportunity to ensure conception with the small number of sperm collected.

Testicular Cancer

The cornerstone evaluation for male infertility is the semen analysis. This is one of the most important fertility test for men because male infertility is present in up to 40% of couples with infertility.

Currently, the main fertility preservation option for men is sperm cryopreservation (freezing). Men who receive a diagnosis of cancer should freeze their sperm on 2-3 occasions prior to receiving chemotherapy or radiation.

Sperm can be frozen on the same or next day after a diagnosis of cancer is made, and can be recollected every 48-72 hours prior to treatment and depending on the clinical circumstance. The advantage of freezing sperm with a Reproductive Endocrinologist (Infertility Specialist) is that intrauterine insemination or preferably IVF can later be used to conceive. Since sperm can only be frozen in small quantities, IVF provides the best opportunity to ensure conception with the small number of sperm collected.

Hodgkin’s Lymphoma

Men treated for Hodgkin's lymphoma may have over 90% risk of long-term azoospermia (lack of sperm production), while patients with testicular cancer may have less than 20% risk of long-term azoospermia. Also, Hodgkin's lymphoma is typically manifested in men aged 20-30 years and later at ages over 50.

Men treated for Hodgkin's lymphoma may have over 90% risk of long-term azoospermia (lack of sperm production), while patients with testicular cancer may have less than 20% risk of long-term azoospermia. Also, Hodgkin's lymphoma is typically manifested in men aged 20-30 years and later at ages over 50.

The disease staging depends on the extent of lymph node involvement and the presence of associated symptoms of fever, night sweats, and weight loss. Treatment includes chemotherapy and/or radiotherapy. The treatment has a high cure rate with over 94% of patients surviving after 10 years.

Treatment with a combination chemotherapy with six or more courses of mechlorethamine, vincristine, procarbazine, and prednisolone (MOPP) or mechlorethamine, vinblastine, procarbazine and prednisolone (MVPP), may result in azoospermia in up to 90% of patients.

Other chemotherapy agents such as the ABVD regimen consisting of doxorubicin, bleomycin, vinblastine, and dacarbazine are less toxic to the testis and may allow for a high recovery of sperm production. After chemotherapy treatment, sperm production may take up to 5 years to return to normal levels.

Sperm cryopreservation prior to chemotherapy should be offered to post-pubertal men. If in vitro fertilization in is combined with intracytoplasmic sperm injection, a conception is possible even with a very low sperm count.

Male Fertility Facts

Do you have questions? We have the aswers. Find below the most commom topics for male infertility.

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